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Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status

Chenfei Zhou, Jun Zhang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 12-23 doi: 10.1007/s11684-019-0685-9

Abstract:

Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the lastThe efficacy of immune checkpoint inhibitors (ICIs) for treatment of refractory GI cancer has been confirmedfor treatment of metastatic solid tumors with mismatch repair deficiency, especially for colorectal cancerachieve higher efficacy than conventional therapy alone in late-stage or even front-line treatment of GI cancercombining immune checkpoint inhibitors with molecular targeted therapy, chemotherapy, or radiotherapy in GI cancer

Keywords： gastrointestinal cancer     immune checkpoint inhibitor     combination therapy    

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Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

Lei Huang,Aman Xu

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 20-31 doi: 10.1007/s11684-016-0493-4

Abstract: While traditional serum assays have limited sensitivity and specificity, gastrointestinal juice may provideHerein, the current progress in the relationship between gastrointestinal fluid analyses and GC is systematicallycombination tests of different category markers could provide important diagnostic and prognostic clues for gastrointestinalGastrointestinal fluid examination could also predict the adverse effects of postgastrectomy, such asThe methods for obtaining the samples of gastrointestinal juice with minimum incision should also be

Keywords： gastrointestinal fluid     gastric carcinoma     biomarker     diagnosis     prognosis     gastrectomy     adverse events    

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A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

Eric C.H. Lai,Kam Man Chung,Stephanie H.Y. Lau,Wan Yee Lau

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 108-111 doi: 10.1007/s11684-014-0344-0

Abstract: a 54-year-old man who developed disseminated intra-abdominal recurrence from a previously resected gastrointestinal

Keywords： gastrointestinal stromal tumour     hemoperitoneum     small bowel GIST     small bowel neoplasm     imatinib    

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Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 317-321 doi: 10.1007/s11684-012-0203-9

Abstract:

In order to find out the potential indicators predicting prognosis of malignant gastrointestinal stromal

Keywords： gastrointestinal stromal tumors     surgery     survival    

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Gastrointestinal damage caused by swallowing multiple magnets

Shiqi Liu, Jianhui Li, Yi Lv

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 280-287 doi: 10.1007/s11684-012-0207-5

Abstract: Various gastrointestinal damages such as necrosis and intestinal perforation or fistula were encountered

Keywords： magnet     ingestion     fistula     perforation    

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High-Throughput Profiling of Serological Immunoglobulin G N-Glycome as a Noninvasive Biomarker of Gastrointestinal Article

Pengcheng Liu, Xiaobing Wang, Aishe Dun, Yutong Li, Houqiang Li, Lu Wang, Yichun Zhang, Cancan Li, Jinxia Zhang, Xiaoyu Zhang, Lixing Ma, Haifeng Hou

Engineering 2023, Volume 26, Issue 7,   Pages 44-53 doi: 10.1016/j.eng.2023.02.008

Abstract: This study aimed to evaluate the diagnostic performance of IgG for gastrointestinal (GI) cancer subtypesA total of 749 GI cancer patients were enrolled from the Cancer Hospital, Chinese Academy of MedicalSciences, including esophageal cancer (EC), gastric cancer (GC), colorectal cancer (CRC), and pancreaticcancer (PC) patients.patients, whereas the abundance of glycans with bisecting Nacetylglucosamine (GlcNAc) was increased in GI cancer

Keywords： Gastrointestinal cancer     Glycosylation     Immunoglobulin G     Diagnostic biomarker    

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Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 87-94 doi: 10.1007/s11684-008-0016-z

Abstract: The biological behavior of gastrointestinal stromal tumors (GISTs) are highly variable.
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Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit

Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 101-111 doi: 10.1007/s11684-019-0698-4

Abstract: employed two commercial kits to determine MSI and forensic short tandem repeat (STR) alternations in 250 gastrointestinal

Keywords： mismatch repair protein deficiency (MMR-D)     microsatellite instability (MSI)     short tandem repeats (STR)     gastrointestinal    

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Ingestible wireless capsules for enhanced diagnostic inspection of gastrointestinal tract

Mahdi RASOULI, Andy Prima KENCANA, Van An HUYNH, Eng Kiat TING, Joshua Chong Yue LAI, Kai Juan WONG, Su Lim TAN, Soo Jay PHEE

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 1,   Pages 40-44 doi: 10.1007/s11465-011-0204-4

Abstract:

Wireless capsule endoscopy has become a common procedure for diagnostic inspection of gastrointestinalpropose and develop two wireless endoscopes with maneuverable vision systems to enhance diagnosis of gastrointestinal

Keywords： wireless capsule endoscopy     ingestible medical device     in-body medical device     miniature actuator     medical robot     medical imaging    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Progress and challenges in RET-targeted cancer therapy

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 207-219 doi: 10.1007/s11684-023-0985-y

Abstract: Oncogenic RET fusions or mutations are found most often in non-small cell lung cancer (NSCLC) and inthyroid cancer, but also increasingly in various types of cancers at low rates.

Keywords： pralsetinib     selpercatinib     RET-alteration     lung cancer     thyroid cancer     tumor-agnostic therapy     drug    

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract: termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancerinvasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer

Keywords： epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

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Metformin for cancer prevention

Yonghua Yang

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 115-117 doi: 10.1007/s11684-011-0112-3

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Orlistat induces ferroptosis-like cell death of lung cancer cells

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 922-932 doi: 10.1007/s11684-020-0804-7

Abstract: synthesis is involved in the progression and treatment resistance of many types of cancers, including lung cancer; however, targeting the lipogenetic pathways for cancer therapy remains an unmet clinical need.we tested the anticancer activity of orlistat, an FDA-approved anti-obesity drug, in human and mouse cancerand we found that orlistat, as a single agent, inhibited the proliferation and viabilities of lung cancerand other types of cancer.

Keywords： orlistat     ferroptosis     FAF2     lung cancer    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract:

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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Title Author Date Type Operation

Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status

Chenfei Zhou, Jun Zhang

Journal Article

Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

Lei Huang,Aman Xu

Journal Article

A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

Eric C.H. Lai,Kam Man Chung,Stephanie H.Y. Lau,Wan Yee Lau

Journal Article

Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Journal Article

Gastrointestinal damage caused by swallowing multiple magnets

Shiqi Liu, Jianhui Li, Yi Lv

Journal Article

High-Throughput Profiling of Serological Immunoglobulin G N-Glycome as a Noninvasive Biomarker of Gastrointestinal

Pengcheng Liu, Xiaobing Wang, Aishe Dun, Yutong Li, Houqiang Li, Lu Wang, Yichun Zhang, Cancan Li, Jinxia Zhang, Xiaoyu Zhang, Lixing Ma, Haifeng Hou

Journal Article

Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Journal Article

Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit

Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li

Journal Article

Ingestible wireless capsules for enhanced diagnostic inspection of gastrointestinal tract

Mahdi RASOULI, Andy Prima KENCANA, Van An HUYNH, Eng Kiat TING, Joshua Chong Yue LAI, Kai Juan WONG, Su Lim TAN, Soo Jay PHEE

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

Progress and challenges in RET-targeted cancer therapy

Journal Article

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article

Metformin for cancer prevention

Yonghua Yang

Journal Article

Orlistat induces ferroptosis-like cell death of lung cancer cells

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article